Variant position: 285 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 487 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HGRGGGALLGDRWILTAAHT IYPKDSVSLRKNQSVNVFLGH
Mouse YGRGGGALLGDRWILTAAHT IYPKDSIYLRRNQNVEVFLGH
Rat YGRGGGALLGDRWILTAAHT IFPKDSIYLRKNKTVNVFLGH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
36 – 487 Complement C1r subcomponent-like protein
245 – 484 Peptidase S1
283 – 283 Charge relay system
296 – 296 N-linked (GlcNAc...) asparagine
A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity.
Lin N.; Liu S.; Li N.; Wu P.; An H.; Yu Y.; Wan T.; Cao X.;
Biochem. Biophys. Res. Commun. 321:329-336(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INDUCTION; VARIANT VAL-285;
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