Variant position: 173 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 241 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SFLTALVSLLSVYVTGVCVA FILLSKSKSNPLRNKEIKEDS
Mouse SFLIVLLALLSVYITGVCVT FIVLFKSKSNGPRSRETKGS-
Rat SLLIVLLALLAVYVTGVCVI FIVLFRSKSNTPRSRETKEDS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 241 Immunoglobulin superfamily member 6
154 – 174 Helical
Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease.
King K.; Moody A.; Fisher S.A.; Mirza M.M.; Cuthbert A.P.; Hampe J.; Sutherland-Craggs A.; Sanderson J.; MacPherson A.J.; Forbes A.; Mansfield J.; Schreiber S.; Lewis C.M.; Mathew C.G.;
Eur. J. Immunogenet. 30:187-190(2003)
Cited for: VARIANTS SER-173 AND LYS-186;
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