Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 911 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GTHKVYVELQELVMDEKNQE LRWMEAARWVQLEENLGENGA
Mouse SSGQVYVELQELMMDQRNQE LQWVEAAHWIGLEENLREDGV
Rat SSSQVYVELQELMMDQRNQE LQWVEAAHWIGLEENLREDGV
Chicken DTYEGYVELHELVLDSRKDP C-WMEAGRWLHLEESMEPGGA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 911 Band 3 anion transport protein
1 – 403 Cytoplasmic
55 – 290 Globular
85 – 85 E -> AR. Impairs expression at the cell membrane.
73 – 88
Novel band 3 variants (bands 3 Foggia, Napoli I and Napoli II) associated with hereditary spherocytosis and band 3 deficiency: status of the D38A polymorphism within the EPB3 locus.
Miraglia del Giudice E.; Vallier A.; Maillet P.; Perrotta S.; Cutillo S.; Iolascon A.; Tanner M.J.; Delaunay J.; Alloisio N.;
Br. J. Haematol. 96:70-76(1997)
Cited for: VARIANT SPH4 ASN-783; VARIANTS ALA-38 AND MET-73;
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