Variant position: 432 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 555 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVAGAACLASVFIPGDLQWL KIIISCLGRMGITMAYEIVCL
Mouse MVAGAACLASVFIPDDLQWL KITVACLGRMGITIAYEMVCL
Rat MVAGAACLASVFIPDDLQWL KITIACLGRMGITMAYEMVCL
Pig VVAGAACLASVFIPEDPHWL RITVLCLGRMGITMAYEMVCL
Rabbit MVAGAACLASVFVPDDLQGL RITVACLGRMGITMAYEMVCL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 555 Solute carrier family 22 member 2
415 – 435 Helical
451 – 451 Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations
243 – 555 Missing. In isoform 3.
427 – 483 DLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPF -> GKFQVKLESYLQDPGERECHGPLIGKPCNLSSKSIWKDKLEGSIWDPSEQIHMASLL. In isoform 2.
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
Leabman M.K.; Huang C.C.; Kawamoto M.; Johns S.J.; Stryke D.; Ferrin T.E.; DeYoung J.; Taylor T.; Clark A.G.; Herskowitz I.; Giacomini K.M.;
Cited for: VARIANT SER-54; CHARACTERIZATION OF VARIANTS ILE-165; ALA-270; CYS-400 AND GLN-432;
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