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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q30154: Variant p.Gly154Ala

HLA class II histocompatibility antigen, DR beta 5 chain
Gene: HLA-DRB5
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Variant information Variant position: help 154 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glycine (G) to Alanine (A) at position 154 (G154A, p.Gly154Ala). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to small size and hydrophobic (A) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help The following alleles of DRB5 are known: DRB5*01:01, DRB5*01:02, DRB5*01:03, DRB5*01:04, DRB5*01:05, DRB5*01:06, DRB5*01:07, DRB5*01:09, DRB5*01:11, DRB5*01:12 DRB5*01:13, DRB5*01:14, DRB5*02:02, DRB5*02:03, DRB5*02:04, DRB5*02:05. The sequence shown is that of DRB5*01:01. Additional information on the polymorphism described.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 154 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 266 The length of the canonical sequence.
Location on the sequence: help RTQTLQHHNLLVCSVNGFYP G SIEVRWFRNSQEEKAGVVST The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 30 – 266 HLA class II histocompatibility antigen, DR beta 5 chain
Topological domain 30 – 227 Extracellular
Domain 126 – 214 Ig-like C1-type
Region 125 – 227 Beta-2
Disulfide bond 146 – 202
Beta strand 137 – 154



Literature citations
Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci.
Wu S.; Saunders T.L.; Bach F.H.;
Nature 324:676-679(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS SER-28 AND ALA-154; Allelic variation in the DR subregion of the human major histocompatibility complex.
Bell J.I.; Denney D. Jr.; Foster L.; Belt T.K.; Todd J.A.; McDevitt H.O.;
Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266; VARIANT ALA-154;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.