Variant position: 502 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 602 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DNYTKAEEILSRSIVKRWAN FAKYGNPNETQNNSTSWPVFK
Mouse VNYTRAEEIFSRSIMKTWAN FAKYGHPNGTQGNSTMWPVFT
Bovine VNYTKAEEIFSRSIMKRWAN FAKYGNPNGTQNNSTRWPVFK
Rabbit VNYTKAEEILSRSIMKRWAN FAKYGNPNGTQNNSTRWPVFK
Cat VNYTRAEEILSRSIMNYWAN FAKYGNPNGTQNNSTRWPAFR
Horse VNYTRAEEILSRSIMKRWAN FAKYGNPNGTQNNSTRWPVFK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
29 – 602 Cholinesterase
483 – 483 N-linked (GlcNAc...) (complex) asparagine
509 – 509 N-linked (GlcNAc...) asparagine
513 – 513 N-linked (GlcNAc...) asparagine
514 – 514 N-linked (GlcNAc...) asparagine
428 – 547
486 – 505
Novel mutations in the BCHE gene in patients with no butyrylcholinesterase activity.
On-Kei Chan A.; Lam C.-W.; Tong S.-F.; Man Tung C.; Yung K.; Chan Y.-W.; Au K.-M.; Yuen Y.-P.; Hung C.-T.; Ng K.-P.; Shek C.-C.;
Clin. Chim. Acta 351:155-159(2005)
Cited for: VARIANTS BCHED CYS-414 AND LEU-502;
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