Variant position: 543 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 602 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human STEQKYLTLNTESTRIMTKL RAQQCRFWTSFFPKVLEMTGN
Mouse STEQKYLTLNTEKSKIYSKL RAPQCQFWRLFFPKVLEMTGD
Bovine SNEQKYFTLNTESPKVNTKL RAQQCRFWTLFFPKVLEITGN
Rabbit STEQKYLTLNTESPRIYTKL RAQQCRFWTLFFPKVLEMTGN
Cat STDQKYLTLNAESPKVYTKL RAQQCRFWTLFFPKVLEMTGN
Horse STEQKYLTLNTESPKVYTKL RAQQCRFWTLFFPKVLELTGN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Genetic basis of the silent phenotype of serum butyrylcholinesterase in three compound heterozygotes.
Maekawa M.; Sudo K.; Kanno T.; Kotani K.; Dey D.C.; Ishikawa J.; Izumi M.; Etoh K.;
Clin. Chim. Acta 235:41-57(1995)
Cited for: VARIANTS BCHED PRO-278; ARG-393; SER-446; CYS-543 AND THR-567;
Genetic mutations of butyrylcholine esterase identified from phenotypic abnormalities in Japan.
Maekawa M.; Sudo K.; Dey D.C.; Ishikawa J.; Izumi M.; Kotani K.; Kanno T.;
Clin. Chem. 43:924-929(1997)
Cited for: VARIANTS BCHED ILE-32 DEL; MET-52; SER-128; PRO-278; ARG-295; ILE-358; ARG-393; SER-446; CYS-543 AND THR-567;
Three point mutations of human butyrylcholinesterase in a Japanese family and the alterations of three-dimensional structure.
Asanuma K.; Yagihashi A.; Uehara N.; Kida T.; Watanabe N.;
Clin. Chim. Acta 283:33-42(1999)
Cited for: VARIANTS BCHED ILE-358; ARG-393 AND CYS-543;
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