Variant position: 380 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 846 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HQWNSRPEFIVCTHTVVSYA EVRAERRRE---LGIEESLPETAA
Mouse HQWNSRPEFIVCTHTVVSYA EVRAERRRE---LGIEESLPE
Rat HQWNSRPEFIVCTHTVVSYA EVRAERRRE---LGVEESLPE
Chicken HQWNSRPEFIVCTHTVVSYA EVRAERRRE---LGIEESLPE
Drosophila HQFNSKPDYVVCTHKVVSYA EVLKDSRKEGQKSGNSNSITN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 846 Circadian locomoter output cycles protein kaput
371 – 845 Interaction with NR3C1
360 – 360 H -> Y. 3-fold increase in PER1 reporter activity by CLOCK-ARNTL/BMAL1. Some reduction of CRY1 inhibition of CLOCK-ARNTL/BMAL1 transcriptional activity.
367 – 367 E -> K. 3-fold increase in PER1 reporter activity by CLOCK-ARNTL/BMAL1. Some reduction of CRY1 inhibition of CLOCK-ARNTL/BMAL1 transcriptional activity; when associated with E-116 and L-601.
No reference for the current variant in UniProtKB/Swiss-Prot.
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