Sequence information
Variant position: 679 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 763 The length of the canonical sequence.
Location on the sequence:
SSSTTSSSTSSSSTGNQGNQ
A YQNRPVAANTLDFGQNGAMD
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSSTTSSSTSSSSTGNQGNQA YQNRPVAANTLDFGQNGAMD
Mouse SSSTTSSSTSSSSTGNQGNQA YQNRPVAANTLDFGQNGAMD
Rat SSSTTSSSTSSSSTGNQGNQA YQNRPVAANTLDFGQNGAMD
Xenopus laevis SSSTTSSSTSSSSTGNQGNQA YQNRPVAANTLDFGQNGTLD
Xenopus tropicalis SSSTTSSSTSSSSTGNQGNQA YQNRPVAANTLDFGQNGTMD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 763
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Region
596 – 679
Disordered
Compositional bias
627 – 679
Polar residues
Alternative sequence
526 – 763
Missing. In isoform 3.
Alternative sequence
530 – 763
Missing. In isoform 2.
Alternative sequence
585 – 763
Missing. In isoform 4.
Literature citations
Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.
Song W.J.; Sternberg L.R.; Kasten-Sportes C.; van Keuren M.L.; Chung S.H.; Slack A.C.; Miller D.E.; Glover T.W.; Chiang P.W.; Lou L.; Kurnit D.W.;
Genomics 38:331-339(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG); VARIANT PRO-679; TISSUE SPECIFICITY;
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-679;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.