Sequence information
Variant position: 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 970 The length of the canonical sequence.
Location on the sequence:
QLKHPSILELYNYFEDSNYV
Y LVLEMCHNGEMNRYLKNRVK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QLKHPSILELYNYFEDSNYVY LVLEMCHNGEMNRYLKNRVK
Mouse QLKHPSVLELYNYFEDNNYVY LVLEMCHNGEMNRYLKNRMK
Rat QLKHPSVLELYNYFEDNNYVY LVLEMCHNGEMNRYLKNRMK
Bovine QLKHPSILELYNYFEDNNYVY LVLEMCHNGEMNRYLKNRRK
Xenopus laevis QLKHPSILELYNYFEDSNYVY LILEMCHNGEVNRYLKNRKK
Xenopus tropicalis QLKHPSILELYNYFEDSNYVY LILEMCHNGEMNRFLKNRKK
Zebrafish RLKHPSVLELYNYFEDSNYVY LVLEMCHNGEMSRYLKERKN
Drosophila RLKHPSVLQLYTFFQDANYVY LVLELAHNGELHRYMNHIAR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 970
Serine/threonine-protein kinase PLK4
Domain
12 – 265
Protein kinase
Beta strand
82 – 90
Literature citations
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-86; HIS-146; THR-226; THR-232; LEU-317; ASP-449; SER-519 AND ASP-830;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.