Sequence information
Variant position: 431 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1388 The length of the canonical sequence.
Location on the sequence:
IGFTYYRENLLLSDSPSCRE
T DSIQSRKNEESQEIQKKLYT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IGFTYYRENLLLSDSPSCRET DSIQSRKNEESQEIQKKLYT
Mouse IGFTYFRENLLLSDSPPCREN DAIQTRKSEESQEIQKKLYA
Rat IGFTYFRENLLLSDSPPCREN DAIQTRKSEESQEIQKKLYA
Pig IGFTYYRENLLLSDSPSCKEN DSIQIRKNEESQEIQKKLYT
Bovine IGFTYYRENLLLSDSPSCKEN DSIQSRKNEESQEIQKKLYT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1388
Rho-associated protein kinase 2
Region
363 – 784
Interaction with PPP1R12A
Coiled coil
429 – 1024
Modified residue
414 – 414
Phosphothreonine; by ROCK2
Literature citations
Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
Takahashi N.; Tuiki H.; Saya H.; Kaibuchi K.;
Genomics 55:235-237(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ASN-431;
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Ishikawa K.; Nagase T.; Suyama M.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 5:169-176(1998)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT ASN-431;
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-431; VAL-601 AND PRO-1194;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.