Sequence information
Variant position: 416 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 487 The length of the canonical sequence.
Location on the sequence:
LEYFEQKEKENQINSFGKSV
P GPLKNSSDWKIPQDGDYEFL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human L-EYFEQKEKENQINSFGKSVP GPLKNSSDWKIPQDGDYEFL
Rhesus macaque L-EYFEQKEKENQINSFGKSVP GPLKNSSDWKIPQDGDYEF
Mouse L-EYFEQKEKENQINSFGKNVS GSLKNSSDWKIPQDGDYEF
Bovine L-EYFEQKEKENQINSFGKSVP GPLQNSSDWKVPQDGDYEF
Chicken L-EYFEQKAKENQVNSFGKNVS GQTKNSSDWKVPQDGDYEF
Xenopus laevis L-EYFEQ--KENQFGTPEKTSP T-STDPSEWKIPLNGDYSF
Xenopus tropicalis L-EYFEQ--KENQFGTPEKTTP APSTDPSEWKIPLNGDYSF
Slime mold VPDYM------NQFKKSDDDVT N---------VPLSDKYS-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 487
Serine/threonine-protein kinase 4
Chain
327 – 487
Serine/threonine-protein kinase 4 18kDa subunit
Modified residue
410 – 410
Phosphoserine
Modified residue
414 – 414
Phosphoserine
Modified residue
433 – 433
Phosphotyrosine
Literature citations
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-162; GLN-310; MET-312; THR-355 AND LEU-416;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.