UniProtKB/SwissProt variant VAR

Cyclin-dependent kinase 10
Gene: CDK10
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Variant information Variant position:

342
Type of variant:

LB/B
Residue change:

From Arginine (R) to Histidine (H) at position 342 (R342H, p.Arg342His).
Physico-chemical properties:

Change from large size and basic (R) to medium size and polar (H)
BLOSUM score:

0
Other resources:

Variant rs55757604 [ dbSNP | Ensembl ]

Sequence information Variant position:

342
Protein sequence length:

360
Location on the sequence:

YFKEKPLPCEPELMPTFPHH R NKRAAPATSEGQSKRCKP
Residue conservation:

Human                         YFKEKPLPCEPELMPTFP----------------------HHRNKRAAPATS---EGQSKRCKP-----------

Mouse                         YFKEKPLPCEPELMPTFP---------------------

Rat                           YFKEKPLPCEPELMPTFP---------------------

Bovine                        YFKEKPLPCEPELMPTFP---------------------

Slime mold                    FFYENPFPQSIEMMPKFPTISKSFKNQNKKQNNNFNNFV

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 360	Cyclin-dependent kinase 10
Region	334 – 360	Disordered
Alternative sequence	161 – 360	Missing. In isoform 6.
Alternative sequence	195 – 360	Missing. In isoform 5.
Alternative sequence	329 – 360	PCEPELMPTFPHHRNKRAAPATSEGQSKRCKP -> RLPISGVCEGCREPG. In isoform 4.

Literature citations
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-168; HIS-342 AND TYR-358;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q15131: Variant p.Arg342His