UniProtKB/SwissProt variant VAR

Mitogen-activated protein kinase 12
Gene: MAPK12
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Variant information Variant position:

103
Type of variant:

LB/B
Residue change:

From Threonine (T) to Methionine (M) at position 103 (T103M, p.Thr103Met).
Physico-chemical properties:

Change from medium size and polar (T) to medium size and hydrophobic (M)
BLOSUM score:

-1
Other resources:

Variant rs34422484 [ dbSNP | Ensembl ]

Sequence information Variant position:

103
Protein sequence length:

367
Location on the sequence:

HENVIGLLDVFTPDETLDDF T DFYLVMPFMGTDLGKLMKHE
Residue conservation:

Human                         HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE

Mouse                         HENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHE

Rat                           HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE

Zebrafish                     HDNVIGLVDVFTADLSLDRFHDFYLVMPFMGTDLGKLMKME

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 367	Mitogen-activated protein kinase 12
Domain	27 – 311	Protein kinase

Literature citations
A genome annotation-driven approach to cloning the human ORFeome.
Collins J.E.; Wright C.L.; Edwards C.A.; Davis M.P.; Grinham J.A.; Cole C.G.; Goward M.E.; Aguado B.; Mallya M.; Mokrab Y.; Huckle E.J.; Beare D.M.; Dunham I.;
Genome Biol. 5:R84.1-R84.11(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANT MET-103; Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-103 AND ASN-230;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P53778: Variant p.Thr103Met