Variant position: 586 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LKGLGHINMMELFSISKEFW EKEVEDIEKYLEDQVNADLPC
Mouse LKGLGGVNVEELFGISKEFW EKEVEEIDRYLEDQVNTDLPY
Rat LKGLGDVNVEELFGISKEFW EKEVEEIDKYLEDQVNADLPY
Bovine LRGLGDVDVKELFHISKEFW EEEVEEIQKYLEEQVNVDLPP
Chicken LKGLEDINLTELFNISKEFW EKEVEEIKQYFEGQVNADLPY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 622 Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
594 – 594 N6-acetyllysine; by p300/EP300
594 – 594 K -> R. Abolishes acetylation and increases protein stability; when associated with R-70 and R-71.
582 – 600
cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
Stoffel M.; Xiang K.S.; Espinosa R. III; Cox N.J.; le Beau M.M.; Bell G.I.;
Hum. Mol. Genet. 2:1-4(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS LEU-184 AND ASP-586;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.