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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q01432: Variant p.Trp450Arg

AMP deaminase 3
Gene: AMPD3
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Variant information Variant position: help 450 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Tryptophan (W) to Arginine (R) at position 450 (W450R, p.Trp450Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and aromatic (W) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In AMPDDE. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 450 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 767 The length of the canonical sequence.
Location on the sequence: help ESKYQYSEPRLSIYGRSPEE W PNLAYWFIQHKVYSPNMRWI The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         ESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWI

Mouse                         DSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWI

Rat                           DSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWI
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 767 AMP deaminase 3
Alternative sequence 208 – 767 Missing. In isoform 1A.



Literature citations
Molecular basis for human erythrocyte AMP deaminase deficiency: screening for the major point mutation and identification of other mutations.
Yamada Y.; Goto H.; Murase T.; Ogasawara N.;
Hum. Mol. Genet. 3:2243-2245(1994)
Cited for: VARIANTS AMPDDE LYS-310; VAL-320; THR-324; CYS-331; CYS-402; ARG-450 AND LEU-585; A rare case of complete human erythrocyte AMP deaminase deficiency due to two novel missense mutations in AMPD3.
Yamada Y.; Goto H.; Wakamatsu N.; Ogasawara N.;
Hum. Mutat. 17:78-78(2001)
Cited for: VARIANTS AMPDDE ARG-450 AND PRO-712;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.