Sequence information
Variant position: 139 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1136 The length of the canonical sequence.
Location on the sequence:
LLADVARFAEGLEKLKECVL
R DDLLEARRPRAHECLGEALR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LLADVARFAEGLEKLKECVLR DDLLEARRPRAHECLGEALR
Mouse LLADVARFAEGLEKLKECVLQ DDLLEARRPLAHECLGEALR
Xenopus laevis LLGDVARFAERLEKLRDVVQD EELKETRRPLAHECLGEALR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1136
Rho GTPase-activating protein 45
Peptide
137 – 145
Minor histocompatibility antigen HA-1
Literature citations
Submission
Mural R.J.; Istrail S.; Sutton G.G.; Florea L.; Halpern A.L.; Mobarry C.M.; Lippert R.; Walenz B.; Shatkay H.; Dew I.; Miller J.R.; Flanigan M.J.; Edwards N.J.; Bolanos R.; Fasulo D.; Halldorsson B.V.; Hannenhalli S.; Turner R.; Yooseph S.; Lu F.; Nusskern D.R.; Shue B.C.; Zheng X.H.; Zhong F.; Delcher A.L.; Huson D.H.; Kravitz S.A.; Mouchard L.; Reinert K.; Remington K.A.; Clark A.G.; Waterman M.S.; Eichler E.E.; Adams M.D.; Hunkapiller M.W.; Myers E.W.; Venter J.C.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANTS HIS-139; ASP-259 AND GLY-439;
Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA).
Arostegui J.I.; Gallardo D.; Rodriguez-Luaces M.; Querol S.; Madrigal J.A.; Garcia-Lopez J.; Granena A.;
Tissue Antigens 56:69-76(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-140; VARIANT HIS-139;
Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes.
Graziano C.; Giorgi M.; Malentacchi C.; Mattiuz P.L.; Porfirio B.;
BMC Med. Genet. 6:36-36(2005)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-140; VARIANT HIS-139;
The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.
den Haan J.M.; Meadows L.M.; Wang W.; Pool J.; Blokland E.; Bishop T.L.; Reinhardus C.; Shabanowitz J.; Offringa R.; Hunt D.F.; Engelhard V.H.; Goulmy E.;
Science 279:1054-1057(1998)
Cited for: PROTEIN SEQUENCE OF 137-145; IDENTIFICATION BY MASS SPECTROMETRY; VARIANT HIS-139;
Definition of the gene encoding the minor histocompatibility antigen HA-1 and typing for HA-1 from genomic DNA.
Tseng L.-H.; Lin M.-T.; Martin P.J.; Pei J.; Smith A.G.; Hansen J.A.;
Tissue Antigens 52:305-311(1998)
Cited for: VARIANT HIS-139;
Therapeutic and diagnostic applications of minor histocompatibility antigen HA-1 and HA-2 disparities in allogeneic hematopoietic stem cell transplantation: a survey of different populations.
Di Terlizzi S.; Zino E.; Mazzi B.; Magnani C.; Tresoldi C.; Perna S.K.; Bregni M.; Rossini S.; Ciceri F.; Bordignon C.; Bonini C.; Fleischhauer K.;
Biol. Blood Marrow Transplant. 12:95-101(2006)
Cited for: VARIANT HIS-139;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.