Variant position: 24 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 91 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human S-AAALAVILIATALCAPASA SPYSSDTTPCCFAYIARPLPR
Rhesus macaque S-AARLAVILVATALCAPASA SPHASDTTPCCFAYIARPLP
Mouse S-AAALTIILTAAALCTPAPA SPYGSDTTPCCFAYLSLALP
Rat SAAASLTVILVAAALCTPVPA SPYGSDTTPCCFAYLSLALP
Bovine S-ATAFAVLLMAAALCAPASA SPYASDTTPCCFAYISRPLP
Cat S-TAAFAVLLTAAAFCTPASA SPYASDTTPCCFAYLSHPLP
Horse F-AAALAVILATATFCTPASA SPYASDTTPCCFAYISRPLP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
24 – 91 C-C motif chemokine 5
27 – 27 O-linked (GalNAc...) serine; partial
28 – 28 O-linked (GalNAc...) serine; partial
31 – 31 T -> A. No effect on inhibition of activity by tick evasin-4.
31 – 31 T -> A. Reduced inhibition of activity by tick evasin-4.
A natural CCL5/RANTES variant antagonist for CCR1 and CCR3.
Capoulade-Metay C.; Ayouba A.; Kfutwah A.; Lole K.; Petres S.; Dudoit Y.; Deterre P.; Menu E.; Barre-Sinoussi F.; Debre P.; Theodorou I.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; VARIANT PHE-24; CHARACTERIZATION OF VARIANT PHE-24;
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