Variant position: 1133 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1158 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LEPEFETQLEPEFEEEEEEE KEEEIATGQAFPFTTVETYTV
Mouse -ETEYGTDLEVEEIEEEEEE EEEEMDTGLTFPLTTVETYTV
Rat -ETEYGPDLEVEELEEEEEE -EEEMDTGLTFPVTTVETYTV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
26 – 1158 Adipocyte enhancer-binding protein 1
941 – 1158 Required for transcriptional repression
1006 – 1158 Interaction with MAPK1 and MAPK3
1108 – 1141 Disordered
1112 – 1136 Acidic residues
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.; Ohara O.; Nagase T.; Kikuno R.F.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLU-1133;
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