Sequence information
Variant position: 1133 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1158 The length of the canonical sequence.
Location on the sequence:
LEPEFETQLEPEFEEEEEEE
K EEEIATGQAFPFTTVETYTV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LEPEFETQLEPEFEEEEEEEK EEEIATGQAFPFTTVETYTV
Mouse -ETEYGTDLEVEEIEEEEEEE EEEMDTGLTFPLTTVETYTV
Rat -ETEYGPDLEVEELEEEEEE- EEEMDTGLTFPVTTVETYTV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
26 – 1158
Adipocyte enhancer-binding protein 1
Region
941 – 1158
Required for transcriptional repression
Region
1006 – 1158
Interaction with MAPK1 and MAPK3
Region
1108 – 1141
Disordered
Compositional bias
1112 – 1136
Acidic residues
Literature citations
Submission
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.; Ohara O.; Nagase T.; Kikuno R.F.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLU-1133;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.