Variant position: 88 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 554 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EELNYTVPGLGPAGEA-FLGQ CRRYEVDWNQSALSCVDPLAS
Mouse EELNYTVPGLGSAGEASFLSQ CMKYEVDWNQSTLDCVDPLS
Rat EELNYTVPGLGPSDEASFLSQ CMRYEVDWNQSTLDCVDPLS
Pig EELNYTVPGLGPAGQA-FPRQ CRRYEVDWNQSTLGCEDPLA
Bovine EELNYTVPGPGPE------SQ CLRYEVDWNQSTLGCLDPLA
Rabbit EELNYTVPGLGATDGA-FVRQ CMRYEVDWNQSSLGCVDPLA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 554 Solute carrier family 22 member 1
43 – 149 Extracellular
71 – 71 N-linked (GlcNAc...) asparagine
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.
Kerb R.; Brinkmann U.; Chatskaia N.; Gorbunov D.; Gorboulev V.; Mornhinweg E.; Keil A.; Eichelbaum M.; Koepsell H.;
Cited for: VARIANTS CYS-61; ARG-88; PHE-160; SER-401 AND MET-420 DEL; CHARACTERIZATION OF VARIANTS CYS-61; ARG-88; PHE-160; SER-401 AND MET-420 DEL;
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