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UniProtKB/Swiss-Prot P12644: Variant p.Ser367Thr

Bone morphogenetic protein 4
Gene: BMP4
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Variant information Variant position: help 367
Type of variant: help LB/B
Residue change: help From Serine (S) to Threonine (T) at position 367 (S367T, p.Ser367Thr).
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (T)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 367
Protein sequence length: help 408
Location on the sequence: help DHLNSTNHAIVQTLVNSVNS S IPKACCVPTELSAISMLYLD
Residue conservation: help 
Human                         DHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD

Mouse                         DHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD

Rat                           DHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD

Bovine                        DHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD

Rabbit                        DHFNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD

Chicken                       DHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD

Xenopus laevis                DHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLD
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 293 – 408 Bone morphogenetic protein 4
Glycosylation 350 – 350 N-linked (GlcNAc...) asparagine
Glycosylation 365 – 365 N-linked (GlcNAc...) asparagine
Disulfide bond 308 – 373
Disulfide bond 337 – 405
Disulfide bond 341 – 407
Disulfide bond 372 – 372 Interchain



Literature citations
Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs).
Felder B.; Stegmann K.; Schultealbert A.; Geller F.; Strehl E.; Ermert A.; Koch M.C.;
Eur. J. Hum. Genet. 10:753-756(2002)
Cited for: VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.