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UniProtKB/Swiss-Prot Q29983: Variant p.Gln274Arg

MHC class I polypeptide-related sequence A
Gene: MICA
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Variant information Variant position: help 274
Type of variant: help LB/B
Residue change: help From Glutamine (Q) to Arginine (R) at position 274 (Q274R, p.Gln274Arg).
Physico-chemical properties: help Change from medium size and polar (Q) to large size and basic (R)
BLOSUM score: help 1
Polymorphism: help The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.
Variant description: help In allele MICA*005, allele MICA*008, allele MICA*010, allele MICA*013, allele MICA*016, allele MICA*019, allele MICA*022, allele MICA*027, allele MICA*033, allele MICA*035, allele MICA*037, allele MICA*039, allele MICA*042, allele MICA*045, allele MICA*048, allele MICA*053, allele MICA*054 and allele MICA*056.
Other resources: help


Sequence information Variant position: help 274
Protein sequence length: help 383
Location on the sequence: help GDVLPDGNGTYQTWVATRIC Q GEEQRFTCYMEHSGNHSTHP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 24 – 383 MHC class I polypeptide-related sequence A
Topological domain 24 – 307 Extracellular
Domain 207 – 296 Ig-like C1-type
Glycosylation 261 – 261 N-linked (GlcNAc...) asparagine
Disulfide bond 225 – 282



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.