Variant position: 600 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 934 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EIVNISSGYVEPMQTLNDVL AQLDAVVSFAHVSNGAPVPYV
Mouse EIVNISSGYVEPMQTLNDVL AHLDAIVSFAHVSNAAPVPYV
Rat EIVNISSGYVEPMQTVNDVL AHLDAVVSFAHVSNAAPVPYV
Bovine EIVNISSGYVEPMQTLNDVL AQLDAVVSFAHVSDAAPVPYV
Drosophila EIIHVAVGYAAPLTLLNNEL AQLDCLVSFAIAARSAPTPYV
Slime mold RTLQIAASFVPLIEDLSSLI ATLDVFVTLSHVSSIAPIPFI
Baker's yeast EIINITLTYTPVFEKLSLVL AHLDVIASFAHTSSYAPIPYI
Fission yeast EVIKIAATYGPPLEAIGQVI AHLDVILSFAHASTVAVIPYV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 934 DNA mismatch repair protein Msh2
589 – 613
Evaluation of screening strategy for detecting hereditary nonpolyposis colorectal carcinoma.
Furukawa T.; Konishi F.; Shitoh K.; Kojima M.; Nagai H.; Tsukamoto T.;
Cited for: VARIANTS HNPCC1 VAL-600 AND PHE-723;
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