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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q96JE7: Variant p.Ser873Asn

Protein transport protein Sec16B
Gene: SEC16B
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Variant information Variant position: help 873 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Asparagine (N) at position 873 (S873N, p.Ser873Asn). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (N) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 873 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1060 The length of the canonical sequence.
Location on the sequence: help ISKPQTPLAARPRSISESSA S SAKEDEKESSDEADKNSPRN The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRN

Mouse                         ISSLQTPAAPRVPSFSEDSAASAKEDEEGSSDGADKPSHPD

Rat                           ISSPQTPLAPRDRSFSEDSAISAKEDEEGTSDGADKPPHPD

Bovine                        ISRPQVPLIPRARSISESSIVSVKEDEEEPPRRQIKIFLKY

Rabbit                        ISTPQELLAPRAQSFSESCPGSVKEADEESSDEAGRKSARS

Chicken                       LAELQE-LSTRARSASESSTASLEEDSQTSSDSPAEEL---

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 1060 Protein transport protein Sec16B
Region 834 – 1060 Disordered
Compositional bias 872 – 906 Basic and acidic residues
Modified residue 858 – 858 Phosphothreonine
Modified residue 868 – 868 Phosphoserine
Modified residue 871 – 871 Phosphoserine
Modified residue 874 – 874 Phosphoserine
Modified residue 882 – 882 Phosphoserine
Modified residue 883 – 883 Phosphoserine
Alternative sequence 625 – 1060 Missing. In isoform 2.



Literature citations
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS HIS-845; ALA-864 AND ASN-873;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.