Variant position: 281 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 425 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PSDQLGDLEQGLSGEPQPRA RAFLAEVKQMRARRKTAKMLM
Mouse PSEQLEAQHQGLCTEPQPRA RAFLAEVKQMRARRKTAKMLM
Rat PSEQLEAQHQGLCTEPQPRA RAFLAEVKQMRARRKTAKMLM
Pig PSDQLEDQGQGPGAEPPPRA RAFLAEVKQMRARRKTAKMLM
Bovine PSVQLEEQGQGLGAEPQPRA RAFLAEVKQMRARRKTAKMLM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 425 Orexin/Hypocretin receptor type 1
236 – 298 Cytoplasmic
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
Olafsdottir B.R.; Rye D.B.; Scammell T.E.; Matheson J.K.; Stefansson K.; Gulcher J.R.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-167; GLN-279; HIS-281 AND VAL-408;
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