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UniProtKB/Swiss-Prot O43614: Variant p.Ile308Val

Orexin receptor type 2
Gene: HCRTR2
Variant information

Variant position:  308
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Isoleucine (I) to Valine (V) at position 308 (I308V, p.Ile308Val).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and hydrophobic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  308
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  444
The length of the canonical sequence.

Location on the sequence:   AVAAEIKQIRARRKTARMLM  I VLLVFAICYLPISILNVLKR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         AVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKR

                              AVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKR

Mouse                         AVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKR

Rat                           AVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKR

Pig                           AVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKR

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 444 Orexin receptor type 2
Transmembrane 305 – 326 Helical; Name=6
Binding site 324 – 324 Suvorexant; antagonist
Mutagenesis 324 – 324 N -> A. Strongly impairs response to orexin-A.
Helix 294 – 328


Literature citations

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Sakurai T.; Amemiya A.; Ishii M.; Matsuzaki I.; Chemelli R.M.; Tanaka H.; Williams S.C.; Richardson J.A.; Kozlowski G.P.; Wilson S.; Arch J.R.S.; Buckingham R.E.; Haynes A.C.; Carr S.A.; Annan R.S.; McNulty D.E.; Liu W.-S.; Terrett J.A.; Elshourbagy N.A.; Bergsma D.J.; Yanagisawa M.;
Cell 92:573-585(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; VARIANT VAL-308;

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
Olafsdottir B.R.; Rye D.B.; Scammell T.E.; Matheson J.K.; Stefansson K.; Gulcher J.R.;
Neurology 57:1896-1899(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-10; THR-11; VAL-293 AND VAL-308;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.