Sequence information
Variant position: 82 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
EAPRMPEAAPPVAPAPAAPT
P AAPAPAPSWPLSSSVPSQKT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EAPRMPEAAPPVAPAPAAPTP AAPAPAPSWPLSSSVPSQKT
DAPRMP----------ATSAP TAPGPAPSWPLSSSVPSPKT
Rhesus macaque EAPRMSEAAPPMAPTPAAPTP AAPAPAPSWPLSSSVPSQKT
Mouse EALRVSGAPAAQDPVTETPGP VAPAPATPWPLSSFVPSQKT
Rat EALQVS-APAAQEPGTEAPAP VAPASATPWPLSSSVPSQKT
Pig DASRVPAPPAA-----TAPAP AAPAPATSWPLSSFVPSQKT
Bovine EAPQMPEPSAP-----AAPPP ATPAPATSWPLSSFVPSQKT
Rabbit EGLRVPAAPAPEAPAPAAPAL AAPAPATSWPLSSSVPSQKT
Sheep EAPQMPEP----------PAQ AALAPATSWPLSSFVPSQKT
Cat DASGMSAVPAP-----AAPAP ATPAPAISWPLSSFVPSQKT
Chicken SDPPPPPPPPPLPLAAAAPPP LNPPTPPRAAPSPVVPSTED
Xenopus laevis NLSEFPDYPLAADMTVLQEGL MGNAVPTV--TSCAVPSTDD
Zebrafish IINDEEYLPGSFDPNFFENVL EEQPQPSTLPPTSTVPETSD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
Region
1 – 320
Interaction with CCAR2
Region
1 – 83
Interaction with HRMT1L2
Region
50 – 96
Disordered
Region
66 – 110
Interaction with WWOX
Compositional bias
64 – 92
Pro residues
Alternative sequence
1 – 132
Missing. In isoform 7, isoform 8 and isoform 9.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.