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UniProtKB/Swiss-Prot P04637: Variant p.Ser99Pro

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 99
Type of variant: help US
Residue change: help From Serine (S) to Proline (P) at position 99 (S99P, p.Ser99Pro).
Physico-chemical properties: help Change from small size and polar (S) to medium size and hydrophobic (P)
BLOSUM score: help -1
Variant description: help In a sporadic cancer; somatic mutation.


Sequence information Variant position: help 99
Protein sequence length: help 393
Location on the sequence: help APTPAAPAPAPSWPLSSSVP S QKTYQGSYGFRLGFLHSGTA
Residue conservation: help 
Human                         APTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTA

                              -SAPTAPGPAPSWPLSSSVPSPKTYPGTYGFRLGFLHSGTA

Rhesus macaque                APTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRLGFLHSGTA

Mouse                         TPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTA

Rat                           APAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTA

Pig                           APAPAAPAPATSWPLSSFVPSQKTYPGSYDFRLGFLHSGTA

Bovine                        APPPATPAPATSWPLSSFVPSQKTYPGNYGFRLGFLQSGTA

Rabbit                        APALAAPAPATSWPLSSSVPSQKTYHGNYGFRLGFLHSGTA

Sheep                         -PAQAALAPATSWPLSSFVPSQKTYPGNYGFRLGFLHSGTA

Cat                           APAPATPAPAISWPLSSFVPSQKTYPGAYGFHLGFLQSGTA

Chicken                       APPPLNPPTPPRAAPSPVVPSTEDYGGDFDFRVGFVEAGTA

Xenopus laevis                LMGNAVPTVT-----SCAVPSTDDYAGKYGLQLDFQQNGTA

Zebrafish                     QPQPSTLPP------TSTVPETSDYPGDHGFRLRFPQSGTA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
Region 1 – 320 Interaction with CCAR2
Region 66 – 110 Interaction with WWOX
Alternative sequence 1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.