Variant position: 105 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAPAPSWPLSSSVPSQKTYQ GSYGFRLGFLHSGTAKSVTCT
Rhesus macaque PAPAPSWPLSSSVPSQKTYH GSYGFRLGFLHSGTAKSVTCT
Mouse PAPATPWPLSSFVPSQKTYQ GNYGFHLGFLQSGTAKSVMCT
Rat PASATPWPLSSSVPSQKTYQ GNYGFHLGFLQSGTAKSVMCT
Pig PAPATSWPLSSFVPSQKTYP GSYDFRLGFLHSGTAKSVTCT
Bovine PAPATSWPLSSFVPSQKTYP GNYGFRLGFLQSGTAKSVTCT
Rabbit PAPATSWPLSSSVPSQKTYH GNYGFRLGFLHSGTAKSVTCT
Sheep LAPATSWPLSSFVPSQKTYP GNYGFRLGFLHSGTAKSVTCT
Cat PAPAISWPLSSFVPSQKTYP GAYGFHLGFLQSGTAKSVTCT
Chicken PPTPPRAAPSPVVPSTEDYG GDFDFRVGFVEAGTAKSVTCT
Xenopus laevis NAVPTV--TSCAVPSTDDYA GKYGLQLDFQQNGTAKSVTCT
Zebrafish QPQPSTLPPTSTVPETSDYP GDHGFRLRFPQSGTAKSVTCT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
102 – 292
1 – 320 Interaction with CCAR2
66 – 110 Interaction with WWOX
100 – 370 Interaction with HIPK1
100 – 300 Required for interaction with ZNF385A
120 – 120 Interaction with DNA
120 – 120 N6-acetyllysine; by KAT6A
1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.
105 – 108
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.