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UniProtKB/Swiss-Prot P04637: Variant p.Gly105Cys

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 105
Type of variant: help LP/P [Disclaimer]
Residue change: help From Glycine (G) to Cysteine (C) at position 105 (G105C, p.Gly105Cys).
Physico-chemical properties: help Change from glycine (G) to medium size and polar (C)
BLOSUM score: help -3
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.


Sequence information Variant position: help 105
Protein sequence length: help 393
Location on the sequence: help PAPAPSWPLSSSVPSQKTYQ G SYGFRLGFLHSGTAKSVTCT
Residue conservation: help 
Human                         PAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCT

                              PGPAPSWPLSSSVPSPKTYPGTYGFRLGFLHSGTAKSVTWT

Rhesus macaque                PAPAPSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCT

Mouse                         PAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCT

Rat                           PASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAKSVMCT

Pig                           PAPATSWPLSSFVPSQKTYPGSYDFRLGFLHSGTAKSVTCT

Bovine                        PAPATSWPLSSFVPSQKTYPGNYGFRLGFLQSGTAKSVTCT

Rabbit                        PAPATSWPLSSSVPSQKTYHGNYGFRLGFLHSGTAKSVTCT

Sheep                         LAPATSWPLSSFVPSQKTYPGNYGFRLGFLHSGTAKSVTCT

Cat                           PAPAISWPLSSFVPSQKTYPGAYGFHLGFLQSGTAKSVTCT

Chicken                       PPTPPRAAPSPVVPSTEDYGGDFDFRVGFVEAGTAKSVTCT

Xenopus laevis                PTVT-----SCAVPSTDDYAGKYGLQLDFQQNGTAKSVTCT

Zebrafish                     LPP------TSTVPETSDYPGDHGFRLRFPQSGTAKSVTCT
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 66 – 110 Interaction with WWOX
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine
Modified residue 120 – 120 N6-lactoyllysine
Alternative sequence 1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.
Turn 105 – 108



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.