Sequence information
Variant position: 105 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
PAPAPSWPLSSSVPSQKTYQ
G SYGFRLGFLHSGTAKSVTCT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAPAPSWPLSSSVPSQKTYQG SYGFRLGFLHSGTAKSVTCT
PGPAPSWPLSSSVPSPKTYPG TYGFRLGFLHSGTAKSVTWT
Rhesus macaque PAPAPSWPLSSSVPSQKTYHG SYGFRLGFLHSGTAKSVTCT
Mouse PAPATPWPLSSFVPSQKTYQG NYGFHLGFLQSGTAKSVMCT
Rat PASATPWPLSSSVPSQKTYQG NYGFHLGFLQSGTAKSVMCT
Pig PAPATSWPLSSFVPSQKTYPG SYDFRLGFLHSGTAKSVTCT
Bovine PAPATSWPLSSFVPSQKTYPG NYGFRLGFLQSGTAKSVTCT
Rabbit PAPATSWPLSSSVPSQKTYHG NYGFRLGFLHSGTAKSVTCT
Sheep LAPATSWPLSSFVPSQKTYPG NYGFRLGFLHSGTAKSVTCT
Cat PAPAISWPLSSFVPSQKTYPG AYGFHLGFLQSGTAKSVTCT
Chicken PPTPPRAAPSPVVPSTEDYGG DFDFRVGFVEAGTAKSVTCT
Xenopus laevis NAVPTV--TSCAVPSTDDYAG KYGLQLDFQQNGTAKSVTCT
Zebrafish QPQPSTLPPTSTVPETSDYPG DHGFRLRFPQSGTAKSVTCT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
DNA binding
102 – 292
Region
1 – 320
Interaction with CCAR2
Region
66 – 110
Interaction with WWOX
Region
100 – 370
Interaction with HIPK1
Region
100 – 300
Required for interaction with ZNF385A
Site
120 – 120
Interaction with DNA
Modified residue
120 – 120
N6-acetyllysine; by KAT6A
Alternative sequence
1 – 132
Missing. In isoform 7, isoform 8 and isoform 9.
Turn
105 – 108
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.