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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Lys132Glu

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 132
Type of variant: help LP/P [Disclaimer]
Residue change: help From Lysine (K) to Glutamate (E) at position 132 (K132E, p.Lys132Glu).
Physico-chemical properties: help Change from large size and basic (K) to medium size and acidic (E)
BLOSUM score: help 1
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 132
Protein sequence length: help 393
Location on the sequence: help GFLHSGTAKSVTCTYSPALN K MFCQLAKTCPVQLWVDSTPP
Residue conservation: help 
Human                         GFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPP

                              GFLHSGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPP

Rhesus macaque                GFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPP

Mouse                         GFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPP

Rat                           GFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPP

Pig                           GFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPP

Bovine                        GFLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPP

Rabbit                        GFLHSGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPP

Sheep                         GFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPP

Cat                           GFLQSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPP

Chicken                       GFVEAGTAKSVTCTYSPVLNKVYCRLAKPCPVQVRVGVAPP

Xenopus laevis                DFQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPP

Zebrafish                     RFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine
Modified residue 120 – 120 N6-lactoyllysine
Modified residue 139 – 139 N6-lactoyllysine
Alternative sequence 1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.
Beta strand 132 – 135



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.