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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Met133Val

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 133
Type of variant: help US
Residue change: help From Methionine (M) to Valine (V) at position 133 (M133V, p.Met133Val).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 133
Protein sequence length: help 393
Location on the sequence: help FLHSGTAKSVTCTYSPALNK M FCQLAKTCPVQLWVDSTPPP
Residue conservation: help 
Human                         FLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPP

                              FLHSGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPPP

Rhesus macaque                FLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPP

Mouse                         FLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPA

Rat                           FLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPP

Pig                           FLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPP

Bovine                        FLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPP

Rabbit                        FLHSGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPP

Sheep                         FLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPP

Cat                           FLQSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPPP

Chicken                       FVEAGTAKSVTCTYSPVLNKVYCRLAKPCPVQVRVGVAPPP

Xenopus laevis                FQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPR

Zebrafish                     FPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine
Modified residue 120 – 120 N6-lactoyllysine
Modified residue 139 – 139 N6-lactoyllysine
Beta strand 132 – 135



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.