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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Gln136His

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 136
Type of variant: help US
Residue change: help From Glutamine (Q) to Histidine (H) at position 136 (Q136H, p.Gln136His).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and polar.
BLOSUM score: help 0
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 136
Protein sequence length: help 393
Location on the sequence: help SGTAKSVTCTYSPALNKMFC Q LAKTCPVQLWVDSTPPPGTR
Residue conservation: help 
Human                         SGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTR

                              SGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPPPNTC

Rhesus macaque                SGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSR

Mouse                         SGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSR

Rat                           SGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTR

Pig                           SGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPPGTR

Bovine                        SGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTR

Rabbit                        SGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPPGTR

Sheep                         SGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTR

Cat                           SGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPPPGTC

Chicken                       AGTAKSVTCTYSPVLNKVYCRLAKPCPVQVRVGVAPPPGSS

Xenopus laevis                NGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPRGSI

Zebrafish                     SGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSV
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine
Modified residue 120 – 120 N6-lactoyllysine
Modified residue 139 – 139 N6-lactoyllysine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.