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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Lys139Glu

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 139
Type of variant: help US
Residue change: help From Lysine (K) to Glutamate (E) at position 139 (K139E, p.Lys139Glu).
Physico-chemical properties: help Change from large size and basic (K) to medium size and acidic (E)
BLOSUM score: help 1
Variant description: help In sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity.
Other resources: help


Sequence information Variant position: help 139
Protein sequence length: help 393
Location on the sequence: help AKSVTCTYSPALNKMFCQLA K TCPVQLWVDSTPPPGTRVRA
Residue conservation: help 
Human                         AKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRA

                              AKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPPPNTCVRA

Rhesus macaque                AKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRA

Mouse                         AKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRA

Rat                           AKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRA

Pig                           AKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPPGTRVRA

Bovine                        AKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRA

Rabbit                        AKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPPGTRVRA

Sheep                         AKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRA

Cat                           AKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPPPGTCVRA

Chicken                       AKSVTCTYSPVLNKVYCRLAKPCPVQVRVGVAPPPGSSLRA

Xenopus laevis                AKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPRGSILRA

Zebrafish                     AKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSVVRA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine
Modified residue 120 – 120 N6-lactoyllysine
Modified residue 139 – 139 N6-lactoyllysine



Literature citations
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
Zong Z.; Xie F.; Wang S.; Wu X.; Zhang Z.; Yang B.; Zhou F.;
Cell 187:2375-2392(2024)
Cited for: FUNCTION; DOMAIN; LACTYLATION AT LYS-120 AND LYS-139; CHARACTERIZATION OF VARIANTS GLU-120; GLN-120; ASN-139; THR-139; GLN-139 AND GLU-139;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.