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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Thr150Ala

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 150
Type of variant: help US
Residue change: help From Threonine (T) to Alanine (A) at position 150 (T150A, p.Thr150Ala).
Physico-chemical properties: help Change from medium size and polar (T) to small size and hydrophobic (A)
BLOSUM score: help 0
Variant description: help In a sporadic cancer; somatic mutation.


Sequence information Variant position: help 150
Protein sequence length: help 393
Location on the sequence: help LNKMFCQLAKTCPVQLWVDS T PPPGTRVRAMAIYKQSQHMT
Residue conservation: help 
Human                         LNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMT

                              LNKLFCQLAKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVT

Rhesus macaque                LNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMT

Mouse                         LNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMT

Rat                           LNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMT

Pig                           LNKLFCQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMT

Bovine                        LNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMT

Rabbit                        LNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMT

Sheep                         LNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMT

Cat                           LNKLFCQLAKTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMT

Chicken                       LNKVYCRLAKPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVA

Xenopus laevis                LNKLFCQLAKTCPLLVRVESPPPRGSILRATAVYKKSEHVA

Zebrafish                     LNKLFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Modified residue 139 – 139 N6-lactoyllysine
Beta strand 148 – 150



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.