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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Thr155Ile

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 155
Type of variant: help US
Residue change: help From Threonine (T) to Isoleucine (I) at position 155 (T155I, p.Thr155Ile).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (I)
BLOSUM score: help -1
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 155
Protein sequence length: help 393
Location on the sequence: help CQLAKTCPVQLWVDSTPPPG T RVRAMAIYKQSQHMTEVVRR
Residue conservation: help 
Human                         CQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRR

                              CQLAKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVVRR

Rhesus macaque                CQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRR

Mouse                         CQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRR

Rat                           CQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRR

Pig                           CQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRR

Bovine                        CQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRR

Rabbit                        CQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRR

Sheep                         CQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRR

Cat                           CQLAKTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTEVVRR

Chicken                       CRLAKPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVAEVVRR

Xenopus laevis                CQLAKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKR

Zebrafish                     CQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Modified residue 139 – 139 N6-lactoyllysine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.