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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Ala159Val

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 159
Type of variant: help US
Residue change: help From Alanine (A) to Valine (V) at position 159 (A159V, p.Ala159Val).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (V)
BLOSUM score: help 0
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 159
Protein sequence length: help 393
Location on the sequence: help KTCPVQLWVDSTPPPGTRVR A MAIYKQSQHMTEVVRRCPHH
Residue conservation: help 
Human                         KTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHH

                              KTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVVRRCPHH

Rhesus macaque                KTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHH

Mouse                         KTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHH

Rat                           KTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHH

Pig                           KTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRRCPHH

Bovine                        KTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRCPHH

Rabbit                        KTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHH

Sheep                         KTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRSPHH

Cat                           KTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTEVVRRCPHH

Chicken                       KPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVAEVVRRCPHH

Xenopus laevis                KTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCPHH

Zebrafish                     KTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHH
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Binding site 179 – 179
Modified residue 139 – 139 N6-lactoyllysine
Beta strand 156 – 165



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.