Variant position: 180 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MAIYKQSQHMTEVVRRCPHH ERCSD-SDGLAPPQHLIRVEGN
Rhesus macaque MAIYKQSQHMTEVVRRCPHH ERCSD-SDGLAPPQHLIRVEG
Mouse MAIYKKSQHMTEVVRRCPHH ERCSD-GDGLAPPQHLIRVEG
Rat MAIYKKSQHMTEVVRRCPHH ERCSD-GDGLAPPQHLIRVEG
Pig MAIYKKSEYMTEVVRRCPHH ERSSDYSDGLAPPQHLIRVEG
Bovine MAIYKKLEHMTEVVRRCPHH ERSSDYSDGLAPPQHLIRVEG
Rabbit MAIYKKSQHMTEVVRRCPHH ERCSD-SDGLAPPQHLIRVEG
Sheep MAIYKKLEHMTEVVRRSPHH ERSSDYSDGLAPPQHLIRVEG
Cat MAIYKKSEFMTEVVRRCPHH ERCPDSSDGLAPPQHLIRVEG
Chicken VAVYKKSEHVAEVVRRCPHH ERCGGGTDGLAPAQHLIRVEG
Xenopus laevis TAVYKKSEHVAEVVKRCPHH ERSVEPGEDAAPPSHLMRVEG
Zebrafish TAIYKKSEHVAEVVRRCPHH ERTPD-GDNLAPAGHLIRVEG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
102 – 292
1 – 320 Interaction with CCAR2
100 – 370 Interaction with HIPK1
100 – 300 Required for interaction with ZNF385A
113 – 236 Required for interaction with FBXO42
116 – 292 Interaction with AXIN1
176 – 176 Zinc
179 – 179 Zinc
183 – 183 Phosphoserine; by AURKB
183 – 183 S -> A. Abolishes strongly phosphorylation.
183 – 183 S -> E. Inhibits slightly its transcriptional activity.
177 – 180
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.