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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Asp184Val

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 184
Type of variant: help US
Residue change: help From Aspartate (D) to Valine (V) at position 184 (D184V, p.Asp184Val).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and hydrophobic (V)
BLOSUM score: help -3
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 184
Protein sequence length: help 393
Location on the sequence: help KQSQHMTEVVRRCPHHERCS D SDGLAPPQHLIRVEGNLRVE
Residue conservation: help
Human                         KQSQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNLRVE

                              KKSEFVTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGNLRA

Rhesus macaque                KQSQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNLRV

Mouse                         KKSQHMTEVVRRCPHHERCSD-GDGLAPPQHLIRVEGNLYP

Rat                           KKSQHMTEVVRRCPHHERCSD-GDGLAPPQHLIRVEGNPYA

Pig                           KKSEYMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGNLRA

Bovine                        KKLEHMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGNLRA

Rabbit                        KKSQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNLRA

Sheep                         KKLEHMTEVVRRSPHHERSSDYSDGLAPPQHLIRVEGNLRA

Cat                           KKSEFMTEVVRRCPHHERCPDSSDGLAPPQHLIRVEGNLHA

Chicken                       KKSEHVAEVVRRCPHHERCGGGTDGLAPAQHLIRVEGNPQA

Xenopus laevis                KKSEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGNLQA

Zebrafish                     KKSEHVAEVVRRCPHHERTPD-GDNLAPAGHLIRVEGNQRA

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Binding site 179 – 179
Modified residue 183 – 183 Phosphoserine; by AURKB
Mutagenesis 183 – 183 S -> A. Abolishes strongly phosphorylation.
Mutagenesis 183 – 183 S -> E. Inhibits slightly its transcriptional activity.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.