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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Asp186Asn

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 186
Type of variant: help US
Residue change: help From Aspartate (D) to Asparagine (N) at position 186 (D186N, p.Asp186Asn).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (N)
BLOSUM score: help 1
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 186
Protein sequence length: help 393
Location on the sequence: help SQHMTEVVRRCPHHERCSDS D GLAPPQHLIRVEGNLRVEYL
Residue conservation: help 
Human                         SQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNLRVEYL

                              SEFVTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGNLRAKY

Rhesus macaque                SQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNLRVEY

Mouse                         SQHMTEVVRRCPHHERCSD-GDGLAPPQHLIRVEGNLYPEY

Rat                           SQHMTEVVRRCPHHERCSD-GDGLAPPQHLIRVEGNPYAEY

Pig                           SEYMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGNLRAEY

Bovine                        LEHMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGNLRAEY

Rabbit                        SQHMTEVVRRCPHHERCSD-SDGLAPPQHLIRVEGNLRAEY

Sheep                         LEHMTEVVRRSPHHERSSDYSDGLAPPQHLIRVEGNLRAEY

Cat                           SEFMTEVVRRCPHHERCPDSSDGLAPPQHLIRVEGNLHAKY

Chicken                       SEHVAEVVRRCPHHERCGGGTDGLAPAQHLIRVEGNPQARY

Xenopus laevis                SEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGNLQAYY

Zebrafish                     SEHVAEVVRRCPHHERTPD-GDNLAPAGHLIRVEGNQRANY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Binding site 179 – 179
Modified residue 183 – 183 Phosphoserine; by AURKB
Mutagenesis 183 – 183 S -> A. Abolishes strongly phosphorylation.
Mutagenesis 183 – 183 S -> E. Inhibits slightly its transcriptional activity.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.