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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Val203Glu

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 203
Type of variant: help US
Residue change: help From Valine (V) to Glutamate (E) at position 203 (V203E, p.Val203Glu).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to medium size and acidic (E)
BLOSUM score: help -2
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 203
Protein sequence length: help 393
Location on the sequence: help SDSDGLAPPQHLIRVEGNLR V EYLDDRNTFRHSVVVPYEPP
Residue conservation: help 
Human                         SD-SDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPP

                              SDSSDGLAPPQHLIRVEGNLRAKYLDDRNTFRHSVVVPYEP

Rhesus macaque                SD-SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEP

Mouse                         SD-GDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEP

Rat                           SD-GDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEP

Pig                           SDYSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEP

Bovine                        SDYSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYES

Rabbit                        SD-SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEP

Sheep                         SDYSDGLAPPQHLIRVEGNLRAEYFDDRNTFRHSVVVPYES

Cat                           PDSSDGLAPPQHLIRVEGNLHAKYLDDRNTFRHSVVVPYEP

Chicken                       GGGTDGLAPAQHLIRVEGNPQARYHDDETTKRHSVVVPYEP

Xenopus laevis                VEPGEDAAPPSHLMRVEGNLQAYYMEDVNSGRHSVCVPYEG

Zebrafish                     PD-GDNLAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Modified residue 183 – 183 Phosphoserine; by AURKB
Mutagenesis 183 – 183 S -> A. Abolishes strongly phosphorylation.
Mutagenesis 183 – 183 S -> E. Inhibits slightly its transcriptional activity.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.