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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Asp208His

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 208
Type of variant: help US
Residue change: help From Aspartate (D) to Histidine (H) at position 208 (D208H, p.Asp208His).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (H)
BLOSUM score: help -1
Variant description: help In a sporadic cancer; somatic mutation.


Sequence information Variant position: help 208
Protein sequence length: help 393
Location on the sequence: help LAPPQHLIRVEGNLRVEYLD D RNTFRHSVVVPYEPPEVGSD
Residue conservation: help 
Human                         LAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSD

                              LAPPQHLIRVEGNLRAKYLDDRNTFRHSVVVPYEPPEVGSD

Rhesus macaque                LAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSD

Mouse                         LAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSE

Rat                           LAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSD

Pig                           LAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSD

Bovine                        LAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYESPEIDSE

Rabbit                        LAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSD

Sheep                         LAPPQHLIRVEGNLRAEYFDDRNTFRHSVVVPYESPEIESE

Cat                           LAPPQHLIRVEGNLHAKYLDDRNTFRHSVVVPYEPPEVGSD

Chicken                       LAPAQHLIRVEGNPQARYHDDETTKRHSVVVPYEPPEVGSD

Xenopus laevis                AAPPSHLMRVEGNLQAYYMEDVNSGRHSVCVPYEGPQVGTE

Zebrafish                     LAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEAPQLGAE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.