Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Ser215Gly

Cellular tumor antigen p53
Gene: TP53
Feedback?
Variant information Variant position: help 215
Type of variant: help US
Residue change: help From Serine (S) to Glycine (G) at position 215 (S215G, p.Ser215Gly).
Physico-chemical properties: help Change from small size and polar (S) to glycine (G)
BLOSUM score: help 0
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 215
Protein sequence length: help 393
Location on the sequence: help IRVEGNLRVEYLDDRNTFRH S VVVPYEPPEVGSDCTTIHYN
Residue conservation: help 
Human                         IRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN

                              IRVEGNLRAKYLDDRNTFRHSVVVPYEPPEVGSDYTTIHYN

Rhesus macaque                IRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIHYN

Mouse                         IRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYK

Rat                           IRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYK

Pig                           IRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN

Bovine                        IRVEGNLRAEYLDDRNTFRHSVVVPYESPEIDSECTTIHYN

Rabbit                        IRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN

Sheep                         IRVEGNLRAEYFDDRNTFRHSVVVPYESPEIESECTTIHYN

Cat                           IRVEGNLHAKYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN

Chicken                       IRVEGNPQARYHDDETTKRHSVVVPYEPPEVGSDCTTVLYN

Xenopus laevis                MRVEGNLQAYYMEDVNSGRHSVCVPYEGPQVGTECTTVLYN

Zebrafish                     IRVEGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVLLN
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Beta strand 214 – 219



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.