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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Val218Met

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 218
Type of variant: help US
Residue change: help From Valine (V) to Methionine (M) at position 218 (V218M, p.Val218Met).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 218
Protein sequence length: help 393
Location on the sequence: help EGNLRVEYLDDRNTFRHSVV V PYEPPEVGSDCTTIHYNYMC
Residue conservation: help 
Human                         EGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMC

                              EGNLRAKYLDDRNTFRHSVVVPYEPPEVGSDYTTIHYNYMC

Rhesus macaque                EGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMC

Mouse                         EGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMC

Rat                           EGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYKYMC

Pig                           EGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNFMC

Bovine                        EGNLRAEYLDDRNTFRHSVVVPYESPEIDSECTTIHYNFMC

Rabbit                        EGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMC

Sheep                         EGNLRAEYFDDRNTFRHSVVVPYESPEIESECTTIHYNFMC

Cat                           EGNLHAKYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNFMC

Chicken                       EGNPQARYHDDETTKRHSVVVPYEPPEVGSDCTTVLYNFMC

Xenopus laevis                EGNLQAYYMEDVNSGRHSVCVPYEGPQVGTECTTVLYNYMC

Zebrafish                     EGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVLLNYMC
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 238 – 238
Beta strand 214 – 219



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.