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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Cys229Gly

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 229
Type of variant: help US
Residue change: help From Cysteine (C) to Glycine (G) at position 229 (C229G, p.Cys229Gly).
Physico-chemical properties: help Change from medium size and polar (C) to glycine (G)
BLOSUM score: help -3
Variant description: help In a sporadic cancer; somatic mutation.


Sequence information Variant position: help 229
Protein sequence length: help 393
Location on the sequence: help RNTFRHSVVVPYEPPEVGSD C TTIHYNYMCNSSCMGGMNRR
Residue conservation: help 
Human                         RNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRR

                              RNTFRHSVVVPYEPPEVGSDYTTIHYNYMCNSSCMGGMNRR

Rhesus macaque                RNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRR

Mouse                         RQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRR

Rat                           RQTFRHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRR

Pig                           RNTFRHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRR

Bovine                        RNTFRHSVVVPYESPEIDSECTTIHYNFMCNSSCMGGMNRR

Rabbit                        RNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRR

Sheep                         RNTFRHSVVVPYESPEIESECTTIHYNFMCNSSCMGGMNRR

Cat                           RNTFRHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRR

Chicken                       ETTKRHSVVVPYEPPEVGSDCTTVLYNFMCNSSCMGGMNRR

Xenopus laevis                VNSGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRR

Zebrafish                     NITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 238 – 238
Binding site 242 – 242
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Beta strand 228 – 236



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.