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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Tyr236Cys

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 236
Type of variant: help LP/P [Disclaimer]
Residue change: help From Tyrosine (Y) to Cysteine (C) at position 236 (Y236C, p.Tyr236Cys).
Physico-chemical properties: help Change from large size and aromatic (Y) to medium size and polar (C)
BLOSUM score: help -2
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 236
Protein sequence length: help 393
Location on the sequence: help VVVPYEPPEVGSDCTTIHYN Y MCNSSCMGGMNRRPILTIIT
Residue conservation: help 
Human                         VVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIIT

                              VVVPYEPPEVGSDYTTIHYNYMCNSSCMGGMNRRPILTIIT

Rhesus macaque                VVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIIT

Mouse                         VVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIIT

Rat                           VVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIIT

Pig                           VVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPILTIIT

Bovine                        VVVPYESPEIDSECTTIHYNFMCNSSCMGGMNRRPILTIIT

Rabbit                        VVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIIT

Sheep                         VVVPYESPEIESECTTIHYNFMCNSSCMGGMNRRPILTIIT

Cat                           VVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPIITIIT

Chicken                       VVVPYEPPEVGSDCTTVLYNFMCNSSCMGGMNRRPILTILT

Xenopus laevis                VCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIIT

Zebrafish                     VFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIIT
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 238 – 238
Binding site 242 – 242
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Beta strand 228 – 236



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.