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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Cys238Ser

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 238
Type of variant: help LP/P [Disclaimer]
Residue change: help From Cysteine (C) to Serine (S) at position 238 (C238S, p.Cys238Ser).
Physico-chemical properties: help Change from medium size and polar (C) to small size and polar (S)
BLOSUM score: help -1
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 238
Protein sequence length: help 393
Location on the sequence: help VPYEPPEVGSDCTTIHYNYM C NSSCMGGMNRRPILTIITLE
Residue conservation: help 
Human                         VPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLE

                              VPYEPPEVGSDYTTIHYNYMCNSSCMGGMNRRPILTIITLE

Rhesus macaque                VPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLE

Mouse                         VPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLE

Rat                           VPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLE

Pig                           VPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPILTIITLE

Bovine                        VPYESPEIDSECTTIHYNFMCNSSCMGGMNRRPILTIITLE

Rabbit                        VPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLE

Sheep                         VPYESPEIESECTTIHYNFMCNSSCMGGMNRRPILTIITLE

Cat                           VPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPIITIITLE

Chicken                       VPYEPPEVGSDCTTVLYNFMCNSSCMGGMNRRPILTILTLE

Xenopus laevis                VPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLE

Zebrafish                     VPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Binding site 238 – 238
Binding site 242 – 242
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.