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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Met246Ile

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 246
Type of variant: help US
Residue change: help From Methionine (M) to Isoleucine (I) at position 246 (M246I, p.Met246Ile).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 246
Protein sequence length: help 393
Location on the sequence: help GSDCTTIHYNYMCNSSCMGG M NRRPILTIITLEDSSGNLLG
Residue conservation: help 
Human                         GSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLG

                              GSDYTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNVLG

Rhesus macaque                GSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLG

Mouse                         GSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLG

Rat                           GSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLG

Pig                           GSDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDASGNLLG

Bovine                        DSECTTIHYNFMCNSSCMGGMNRRPILTIITLEDSCGNLLG

Rabbit                        GSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLG

Sheep                         ESECTTIHYNFMCNSSCMGGMNRRPILTIITLEDSRGNLLG

Cat                           GSDCTTIHYNFMCNSSCMGGMNRRPIITIITLEDSNGKLLG

Chicken                       GSDCTTVLYNFMCNSSCMGGMNRRPILTILTLEGPGGQLLG

Xenopus laevis                GTECTTVLYNYMCNSSCMGGMNRRPILTIITLETPQGLLLG

Zebrafish                     GAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 241 – 248 Interaction with the 53BP2 SH3 domain
Binding site 238 – 238
Binding site 242 – 242
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Turn 243 – 248



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.