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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Ile254Met

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 254
Type of variant: help US
Residue change: help From Isoleucine (I) to Methionine (M) at position 254 (I254M, p.Ile254Met).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Variant description: help In a sporadic cancer; somatic mutation.


Sequence information Variant position: help 254
Protein sequence length: help 393
Location on the sequence: help YNYMCNSSCMGGMNRRPILT I ITLEDSSGNLLGRNSFEVRV
Residue conservation: help 
Human                         YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRV

                              YNYMCNSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRV

Rhesus macaque                YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRV

Mouse                         YKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRV

Rat                           YKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRV

Pig                           YNFMCNSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRV

Bovine                        YNFMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRV

Rabbit                        YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRV

Sheep                         YNFMCNSSCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRV

Cat                           YNFMCNSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRV

Chicken                       YNFMCNSSCMGGMNRRPILTILTLEGPGGQLLGRRCFEVRV

Xenopus laevis                YNYMCNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRV

Zebrafish                     LNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRV
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Binding site 238 – 238
Binding site 242 – 242
Modified residue 269 – 269 Phosphoserine; by AURKB
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Beta strand 251 – 258



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.