Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Thr256Ile

Cellular tumor antigen p53
Gene: TP53
Feedback?
Variant information Variant position: help 256
Type of variant: help US
Residue change: help From Threonine (T) to Isoleucine (I) at position 256 (T256I, p.Thr256Ile).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (I)
BLOSUM score: help -1
Variant description: help In a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation.


Sequence information Variant position: help 256
Protein sequence length: help 393
Location on the sequence: help YMCNSSCMGGMNRRPILTII T LEDSSGNLLGRNSFEVRVCA
Residue conservation: help 
Human                         YMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA

                              YMCNSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCA

Rhesus macaque                YMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA

Mouse                         YMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCA

Rat                           YMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCA

Pig                           FMCNSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCA

Bovine                        FMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCA

Rabbit                        YMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA

Sheep                         FMCNSSCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRVCA

Cat                           FMCNSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRVCA

Chicken                       FMCNSSCMGGMNRRPILTILTLEGPGGQLLGRRCFEVRVCA

Xenopus laevis                YMCNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCA

Zebrafish                     YMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Binding site 238 – 238
Binding site 242 – 242
Modified residue 269 – 269 Phosphoserine; by AURKB
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Beta strand 251 – 258



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.