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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Ser261Ile

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 261
Type of variant: help US
Residue change: help From Serine (S) to Isoleucine (I) at position 261 (S261I, p.Ser261Ile).
Physico-chemical properties: help Change from small size and polar (S) to medium size and hydrophobic (I)
BLOSUM score: help -2
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 261
Protein sequence length: help 393
Location on the sequence: help SCMGGMNRRPILTIITLEDS S GNLLGRNSFEVRVCACPGRD
Residue conservation: help 
Human                         SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRD

                              SCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCACPGRD

Rhesus macaque                SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRD

Mouse                         SCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRD

Rat                           SCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRD

Pig                           SCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCACPGRD

Bovine                        SCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPGRD

Rabbit                        SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRD

Sheep                         SCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRVCACPGRD

Cat                           SCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRVCACPGRD

Chicken                       SCMGGMNRRPILTILTLEGPGGQLLGRRCFEVRVCACPGRD

Xenopus laevis                SCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCACPGRD

Zebrafish                     SCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRD
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Binding site 242 – 242
Modified residue 269 – 269 Phosphoserine; by AURKB
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Beta strand 260 – 262



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.